b'Rosemary for the Brain inpammasome is a critical compo- Vitamin D and nent of the innate immune sys- Autoimmune Diseasetem that is responsible for theDaily supplementation with 2,000 IU/activation of some inpammatoryday of Vitamin D or a combination of Vi-responses.Activationofthetamin D and omega-\x16 fatty acids for five 1L53\x16inpammasomehasyears can reduce the incidence of auto-been linked with several seri- immune disease, according to a study of ous inpammatory disorders,more than 25,000 older adults. It was also whichincludeAlzheimersobserved that after two years of supple-disease, Parkinsonism, diabetes, and atheroscle- mentation, the beneficial effects of supple-rosis.There have also been reports that unregu- mentation were more evident. lated 1L53\x16 inpammasome activation may po- Autoimmune diseases typically mani-The herb rosemary (5osmarinus ocina- tentially contribute to the severity of COVID-19fest as an inpammatory condition of var-lis) has been used therapeutically in traditionaland its aftermath. The researchers contend thatious tissue groups, such as the joints, the medicines throughout the World. Rosemary isthe effect of rosemary compounds on 1L53\x16skin, and even organs. They are the third leading cause of morbidity in the industri-known as a cephalic herb in the traditionalinpammasome activation can also have antiox- alized world. In the study, all incident au-system of herb classification. A cephalic herb isidant, anti-inpammatory, and neuroprotectivetoimmune diseases confirmed by medical indicated for anything related to the head, sucheffectsonbrain-relatedpost-infectionsymp- record review were included: rheumatoid as memory loss, headache, eye problems, andtoms of SARS-CoV-2, termed long-COVID,arthritis, polymyalgia rheumatica, auto-the likeboth in men and women. Recent re- including neurological after-effects such as anx- immune thyroid disease, systemic lupus search shows that it might also be useful againstiety and brain fog. erythematosus, psoriasis, and others. Vi-brainproblemslikeAlzheimersdiseaseandSatoh T, Trudler D, Oh C, et al., Potential Therapeu- tamin-D supplementation for five years, Parkinsonism, as well as COVID-19.tic Use of the Rosemary Diterpene Carnosic Acid forwith or without omega-3 fatty acids, re-Alzheimers Disease, Parkinsons Disease, and Long- duced autoimmune disease by 22%. The SomeresearchfocusedontheabilityofCOVID through NRF2 Activation to Counteract theresearchers also commented that the ben-certain chemical constituents of rosemary to1/53\x16Inflammasome\x0f Antioxidants\x0f \x15\x13\x15\x15\x1e \x14\x14\x1d\x14\x15\x17\x0f inhibit the 1L53\x16 inpammasome. The 1L53\x16doi.org/10.3390/antiox11010124.Ibuprofen andglomerularfiltrationrate,keyfactorsin Kidney Damageevaluating kidney function. They found that 1ew research confirms that combin- in people with certain medical profiles, the ing diuretics and antihypertensive drugs,triple whammy can cause acute kidney inju-inparticularrenin-angiotensinsystemry, which in some cases can be permanent.inhibitors (RAS inhibitors), with ibupro- According to Anita Layton, professor of fen can significantly increase the risk ofapplied mathematics at Waterloo and Can-acute kidney injury. This phenomenon isada150ResearchChairinMathematical known as triple whammy. Diuretics andBiology and Medicine, Its not that every-RAS inhibitors are commonly prescribedone who happens to take this combination for high blood pressure. Ibuprofen is aof drugs is going to have problems, but the popular pain-reliever that is available overresearch shows its enough of a problem that the counter. you should exercise caution.A research team at the University of WaterloousedcomputermodelingtoLeete J, Wang C, Lpez-Hernndez F, et al., Deter- eficial effects continued to increase over mining risk factors for triple whammy acute kidney in-investigate the interactions of the threejury, Mathematical Biosciences, 2022; 347:108809, doi. time, and that they will continue to follow drugs and their impact on creatinine andorg/10.1016/j.mbs.2022.108809. the participants for two years in an exten-sion study to test the time course of this autoimmune-disease reduction effect. This is important research because there are few known effective treatments for auto-immune disease and the supplements are nontoxic and well tolerated.Hahn J, Cook N, Alexander E, et al., Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial, The British Medical Journal,\x15\x13\x15\x15\x0f 376:e066452, doi.org/10.1136/bmj-2021-066452.H EALTHF REEDOMN EWS /S UMMER2022 31NHF_Summer40-2_2022_Linda_08-09-2022.indd 31 8/10/22 11:10 AM'