b'diet that avoids sugar and processedtreated all of his patients with kind- that he successfully treated thousands foods, can prevent and even reverse aness, respect, and adequate doses ofof schizophrenia patients with niacin. variety of diseases. This fundamentalniacinamide. Soon after starting nia- He also had excellent success treating orthomolecular theme is developed incinamide treatment with up to 2,000depression and showed that niacin low-thechapterPandeficiencyDisease.mg or more per day, taken in dividedered total cholesterol. Hoffer then ex-This theme is based on avoiding defi- doses,thepatientsreportedlybe- plains that niacin is not dangerous or ciencies of vitamins and minerals thatcame easy to take care of medicallytoxic at tolerable doses, and that ade-contribute to a wide variety of condi- andhadastonishingimprovementsquate doses of vitamins (in particular, tions. Some vitamins are needed onlyin their health. Kaufman took theirniacin) produce a recovery rate of 90 in small milligram or microgram dailycomplaints seriously and found thatpercent in schizophrenics.doses, but others, such as Vitamin Ca niacin deficiency was independentNiacin is a vitamin, not a drug. Each and niacin, are needed in much higherof family income. Well-to-do familiesindividual may require a different daily doses, depending upon the bodys statecould afford a nutritionally good diet,dose.Dr.Hoffersays,Apersons ofstress,inflammation,anddisease.even if they did not do so.upper limit is that amount which causes The optimal dose varies with the indi- Althoughby1940enrichedflournausea, and, if not reduced, vomiting. vidual and the state of inflammationwasfortifiedwiththiamine,niacin,The dose should never be allowed to and disease because biochemical stressriboflavin and iron, Dr. Kaufman re- remain at this upper limit. The usual in the body can deplete vitamins andalized that for most individuals, thedose range is up to 3,000 mg daily, di-cause deficiencies, which in turn candoses of these essential nutrients fromvided into three doses, but occasion-cause many different types of disease. foods made with enriched flour wereally some patients may need more. The The book contains several interest- inadequate. So, his treatment with ad- toxic dose for dogs is about 5,000 mil-ing and significant new sections andequate doses of niacinamide becameligrams per 2.2 pounds (1 kilogram) chapters. The chapter entitled Revers- more widely appreciated and soon hisbodyweight.Wedonotknowthe ing Arthritis with Niacinamide: Thepractice was full. Patients recoveredtoxic dose for humans since niacin Pioneering Work of William Kaufman,with a high degree of wellness andhas never killed anyone. But what M.D., Ph.D. has been expanded, nowmaintained this as long as they con- about that niacin flush? Most peo-including some of Dr. Kaufmans notestinued taking niacinamide.ple flush when they first start taking and a memoir written up as his finalThenewsectiononerectiledys- high doses and gradually get adapted unpublished paper. NiacinThe Realfunction (ED) may also interest manyto it, unless they stop for a few days Story is the only book in print to pres- readers.Adequatedosesofniacinand then resume. A few cannot ever ent Kaufmans own case notes and nia- taken long-term can help to preventget used to it and take no-flush nia-cinamide protocol details. In these newatherosclerosis, hyperlipidemia, andcin. The intensity of the flush is vari-sections, Dr. Kaufman documents hisrelated coronary disease, and it also isable. Generally, the people who need discovery of niacin and niacinamidea vasodilator. Because niacin (but notit the most flush the least. That in-treatments during his medical educa- niacinamide) normalizes blood lipids, tion, along with his observations ofits long-term circulatory benefits maycludes arthritics, schizophrenics, and the nutritional deficiencies in the typi- facilitate a males erection. While theelderlypeoplewithcardiovascular cal diet that caused pellagra (caused byvasodilation produced by niacin is notdisease. Some schizophrenics do not a severe deficiency of niacin) and thatas long as one produced by ED drugs,flush until they get welland then also tended to cause osteoarthritis.the niacin flush typically lasts aboutthey do. But the presence of the flush Many of the patients in the earlyhalfanhour.Butsinceniacinalsooritsintensitycannotbeuniquely years of his practice in the 1940s werehelps to improve mood and possiblyused to measure the need as there are referredbyotherphysicianswhosexual interest, generally the sense oftoo many variables such as food in wanted to get rid of their most com- calmness from a goodly dose of niacinthe stomach, whether the drink with plaining and difficult patients. At themay tend to diminish passion. In a re- it is hot or cold, the kind of food, time, the only treatments for arthritislated topic, adequate doses of niacinother medication. Antipsychotics re-were aspirin, hot paraffin dips, or heatand the consequential flush that dilatesduce the intensity of the flush as do treatment of joints. With his carefulblood vessels have been employed byaspirin and antihistamines.observationsofsymptomatology,people to ameliorate Raynauds syn- In this revised edition of NiacinDr.Kaufmanrealizedthatmostofdrome (cold hands and feet due to re- The Real Story, authors Hoffer, Foster, these patients had a niacin deficiency,duced blood flow). and Saul clearly present the practical de-proven by their rapid improvement inThere are several new appendices,tails of niacin treatment. Inevitable phy-health after niacinamide treatment. HeincludinganinterviewwithAbramsician skepticism, and questions about summarized the deficiency symptomsHoffer, M.D., Ph.D. Dr. Hoffer, a bril- niacins proven safety and effectiveness, in detail and further reported that heliant physician and scientist, explainsare thoroughly addressed in this book as H ealtHF reedomN ews /s ummer2023 27'